Pola Distribusi Imunoekspresi P63 Pada Hiperplasia Prostat Sebagai Indikator Keganasan

Yang disebabkan oleh pertumbuhan berlebihan dari epitel dan jaringan fibromuskuler dari transition zone dan daerah periurethral. BPH sangat sering terjadi, beberapa peneliti melaporkan bahwa BPH mempunyai risiko lebih besar untuk menjadi karsinoma, tetapi peneliti-peneliti lain menyatakan tidak ada kenaikan risiko untuk menjadi karsinoma.Lesi-lesi prakarsinoma dapat berbentuk PIN (Prostatic Intraepithelial Neoplasia) atau Hiperplasia Adenomatosa Atipik, tetapi jarang dilaporkan pada pemeriksaan histopatologi biopsi prostat dan prostatektomi, sehingga kita tidak dapat memprediksi hiperplasia prostat tersebut, apakah suatu BPH biasa atau ada indikasi keganasan.Telah dilakukan penelitian pada 30 blok parafin hiperplasia prostat dan 30 blok parafin adenokarsinoma prostat yang diperoleh dari bagian Patologi Anatomi FKUP/RSHS Bandung dan dilakukan pulasan imunohistokimia dengan anti-P63. Ditentukan persentase imunoekspresi P63 pada asini-asini hiperplasia prostat dan adenokarsinoma prostat. Perbandingan imunoekspresi P63 pada hiperplasia prostat dengan adenokarsinoma prostat dianalisis secara statistik menggunakan metode ROC (Receiver Operating Characteristic curve).Dari hasil perhitungan statistik pada persentase imunoekspresi P63 pada asini-asini hiperplasia prostat dan adenokarsinoma prostat, diperoleh cut off (titik potong) yaitu batas persentase imunoekspresi P63 untuk memprediksi apakah suatu hiperplasia prostat akan berubah menuju ke arah adenokarsinoma prostat atau tidak. Persentase jumlah asini yang imunoreaktif continuous, incontinuous dan tidak imunoreaktif dapat digunakan sebagai indikator untuk memprediksi keganasan pada hiperplasia prostat, tetapi yang lebih baik digunakan adalah persentase asini yang continuous, yaitu 0,07 ; bila kita mempunyai sediaan hiperplasia prostat baru dari biopsi dan imunoreaktivitas asini terhadap anti-P63 < 7%, hiperplasia prostat tersebut diprediksi mengarah ke adenokarsinoma prostat. Bila imunoreaktivitas asini terhadap anti-P63 > 7%, hiperplasia prostat tersebut belum mengarah ke adenokarsinoma prosta

ALTERNATIVE RESOLUTION OF INTELLECTUAL PROPERTY DISPUTES AS PART OF INVESTMENT IN THE CREATIVE INDUSTRY SECTOR UNDER INDONESIAN LAW

Purpose: The amount of investment in Indonesia both foreign and domestic increases in number each year. One of the growing investment in Indonesia is the creative industry. Creativity from this creative industry produces a variety of works protected by intellectual property. The development of intellectual property law advanced rapidly. One form of intellectual property is copyright. The many interests in the implementation of this copyright cause some problems and disputes. Indonesia itself recognizes some non-court settlement disputes namely arbitration and mediation so that intellectual property may remain protected. Methodology: This research study gathered secondary data from literature review, online article, dialogues and different document available on the internet regarding the copyright law. In addition, this research study has analysed different Indonesian law regarding copyright. Main Findings: There are rights in copyright protected by law. In-Law No. 28 of 2014 it is possible to settle disputes outside the court through several methods. Article 95 of Law No. 28 of 2014 on Copyright stipulates that Settlement of Copyright disputes may be made through alternative dispute resolution, arbitration, or courts. Implications/Applications: The findings of the study are helpful in gaining knowledge regarding law available regarding copyright and settlement of Copyright disputes through alternative dispute resolution, arbitration, or courts, etc

An optimized resilient advance bandwidth scheduling for media delivery services

Part 3: Evaluation and Experimental Study of Rich Network ServicesInternational audienceIn IP-based media delivery services, we often deal with predictable network load and traffic, making it beneficial to use advance reservations even when network failure occurs. In such a network, to offer reliable reservations, fault-tolerance related features should be incorporated in the advance reservation system. In this paper, we propose an optimized protection mechanism in which backup paths are selected in advance to protect the transfers when any failure happens in the network. Using a shared backup path protection, the proposed approach minimizes the backup capacity of the requests while guaranteeing 100% single link failure recovery. We have evaluated the quality and complexity of our proposed solution and the impact of different percentages of backup demands and timeslot sizes have been investigated in depth. The presented approach has been compared to our previously-designed algorithm as a baseline. Our simulation results reveal a noticeable improvement in request acceptance rate, up to 9.2%. Moreover, with fine-grained timeslot sizes and under limited network capacity, the time complexity of the proposed solution is up to 14% lower

Prevalence of Self-Medication of Psychoactive Stimulants and Antidepressants among Undergraduate Pharmacy Students in Twelve Pakistani Cities

Purpose: To evaluate the prevalence of self-medication of psychoactive stimulants and antidepressants among pharmacy students of Pakistan.Methods: A cross-sectional survey on self-medication of psychoactive stimulants and antidepressants among pharmacy students was conducted with a structured and validated questionnaire distributed to a total of 2981 final year undergraduate pharmacy students in 12 major Pakistani cities (Karachi, Lahore, Islamabad, Rawalpindi, Sargodha, Dera Ismail Khan, Abbottabad, Bahawalpur, Hyderabad, Faisalabad, Multan and Peshawar) of Pakistan. Out of this, 2516 (718 male and 1798 female) students completed and returned the questionnaire.Results: Prevalence of self-medication of psychoactive stimulants was 1.31 (1.13 – 1.75 for 95% CI) and antidepressants was 8.34 (8.03 – 8.85 for 95% CI). A majority of the students (63 %) identified academic competition as a driving force for indulging in self-medication of psychoactive stimulants while nearly all the students (96 %)admitted using antidepressants to obtain relief from the pressure of studies (p < 0.05).Conclusion: Pakistani pharmacy students, despite being aware of the hazards of psychoactive stimulants, indulge in self-medication. Prevalence of self-medication with antidepressants is very high among the students due to the pressure of studies. Primarily, academic competition is the major driving force for the use of psychoactive stimulants.Keywords: Self-medication, Psychoactive stimulants, Antidepressants, Pharmacy students, Academicpressur

SVCEval-RA: an evaluation framework for adaptive scalable video streaming

[EN] Multimedia content adaption strategies are becoming increasingly important for effective video streaming over the actual heterogeneous networks. Thus, evaluation frameworks for adaptive video play an important role in the designing and deploying process of adaptive multimedia streaming systems. This paper describes a novel simulation framework for rate-adaptive video transmission using the Scalable Video Coding standard (H.264/SVC). Our approach uses feedback information about the available bandwidth to allow the video source to select the most suitable combination of SVC layers for the transmission of a video sequence. The proposed solution has been integrated into the network simulator NS-2 in order to support realistic network simulations. To demonstrate the usefulness of the proposed solution we perform a simulation study where a video sequence was transmitted over a three network scenarios. The experimental results show that the Adaptive SVC scheme implemented in our framework provides an efficient alternative that helps to avoid an increase in the network congestion in resource-constrained networks. Improvements in video quality, in terms of PSNR (Peak Signal to Noise Ratio) and SSIM (Structural Similarity Index) are also obtained.Castellanos Hernández, WE.; Guerri Cebollada, JC.; Arce Vila, P. (2017). SVCEval-RA: an evaluation framework for adaptive scalable video streaming. Multimedia Tools and Applications. 76(1):437-461. doi:10.1007/s11042-015-3046-yS437461761Akhshabi S, Begen AC, Dovrolis C (2011) An experimental evaluation of rate-adaptation algorithms in adaptive streaming over HTTP. In: Proceedings of the second annual ACM conference on Multimedia systems. ACM, pp 157–168Alabdulkarim MN, Rikli N-E (2012) QoS Provisioning for H.264/SVC Streams over Ad-Hoc ZigBee Networks Using Cross-Layer Design. In: 8th International Conference on Wireless Communications, Networking and Mobile Computing (WiCOM). pp 1–8Birkos K, Tselios C, Dagiuklas T, Kotsopoulos S (2013) Peer selection and scheduling of H. 264 SVC video over wireless networks. In: Wireless Communications and Networking Conference (WCNC), 2013 IEEE. pp 1633–1638Castellanos W (2014) SVCEval-RA - An Evaluation Framework for Adaptive Scalable Video Streaming. In: SourceForge Project. http://sourceforge.net/projects/svceval-ra/ . Accessed 1 May 2015Castellanos W, Guerri JC, Arce P (2015) A QoS-aware routing protocol with adaptive feedback scheme for video streaming for mobile networks. Comput Commun. http://dx.doi.org/10.1016/j.comcom.2015.08.012Castellanos W, Arce P, Acelas P, Guerri JC (2012) Route Recovery Algorithm for QoS-Aware Routing in MANETs. 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Multimed Tools Appl 1–20. doi: 10.1007/s11042-014-2034-ySchwarz H, Marpe D, Wiegand T (2007) Overview of the Scalable Video Coding Extension of the H.264/AVC Standard. IEEE Trans Circ Syst Video Technol 17:1103–1120. doi: 10.1109/TCSVT.2007.905532Seo H-Y (2013) An Efficient Transmission Scheme of MPEG2-TS over RTP for a Hybrid DMB System. ETRI J 35:655–665. doi: 10.4218/etrij.13.0112.0124Sohn H, Yoo H, De Neve W, et al. (2010) Full-Reference Video Quality Metric for Fully Scalable and Mobile SVC Content. IEEE Trans Broadcast 56:269–280. doi: 10.1109/TBC.2010.2050628Sousa-Vieira M-E (2011) Suitability of the M/G/∞ process for modeling scalable H.264 video traffic. In: Analytical and Stochastic Modeling Techniques and Applications. Springer, pp 149–158Tanwir S, Perros H (2013) A Survey of VBR Video Traffic Models. IEEE Commun Surv Tutor 15:1778–1802. doi: 10.1109/SURV.2013.010413.00071Tanwir S, Perros HG (2014) VBR Video Traffic Models. Wiley, HobokenThe Network Simulator (NS-2). http://www.isi.edu/nsnam/ns . Accessed 6 Feb 2015Unanue I, Urteaga I, Husemann R, et al. (2011) A Tutorial on H. 264/SVC Scalable Video Coding and its Tradeoff between Quality, Coding Efficiency and Performance. Recent Advances on Video Coding 1–24.Van der Auwera G, David PT, Reisslein M, Karam LJ (2008) Traffic and quality characterization of the H. 264/AVC scalable video coding extension. Adv Multimedia 2008:1Wang Y, Claypool M (2005) RealTracer—Tools for Measuring the Performance of RealVideo on the Internet. Multimed Tools Appl 27:411–430. doi: 10.1007/s11042-005-3757-6Wang Z, Lu L, Bovik AC (2004) Video quality assessment based on structural distortion measurement. Signal Process Image Commun 19:121–132. doi: 10.1016/S0923-5965(03)00076–6Wien M, Schwarz H, Oelbaum T (2007) Performance Analysis of SVC. 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Cytotoxicity against A549 Human Lung Cancer Cell Line via the Mitochondrial Membrane Potential and Nuclear Condensation Effects of Nepeta paulsenii Briq., a Perennial Herb

The genus Nepeta belongs to the largest Lamiaceae family, with 300 species, which are distributed throughout the various regions of Africa, Asia, India, and America. Along with other plant families distinguished by their medicinal and therapeutic values, the Nepeta genus of Lameaceae remains relatively valuable. Hence, the phytochemicals of N. paulsenii Briq. were extracted using different plant parts, i.e., leaves, stem, roots, flowers, and the whole plant by using various solvents (ethanol, water, and ethyl acetate), obtaining 15 fractions. Each extract of dried plant material was analyzed by FT-IR and GC-MS to identify the chemical constituents. The cytotoxicity of each fraction was analyzed by MTT assay and mitochondrial membrane potential and nuclear condensation assays against lung cancer cells. Among the ethyl acetate and ethanolic extracts, the flowers showed the best results, with IC50 values of 51.57 μg/mL and 50.58 μg/mL, respectively. In contrast, among the water extracts of the various plant segments, the stem showed the best results, with an IC50 value of 123.80 μg/mL. 5-flourouracil was used as the standard drug, providing an IC50 value of 83.62 μg/mL. The Hoechst 33342 stain results indicated apoptotic features, i.e., chromatin dissolution and broken down, fragmented, and crescent-shaped nuclei. The ethanolic extracts of the flowers showed more pronounced apoptotic effects on the cells. The mitochondrial membrane potential indicated that rhodamine 123 fluorescence signals suppressed mitochondrial potential due to the treatment with the extracts. Again, the apoptotic index of the ethanolic extract of the flowers remained the highest. Hence it can be concluded that the flower part of N. paulsenii Briq. was found to be the most active against the A459 human lung cancer cell line

Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency

Life-threatening pulmonary influenza can be caused by inborn errors of type I and III IFN immunity. We report a 5-yr-old child with severe pulmonary influenza at 2 yr. She is homozygous for a loss-of-function IRF9 allele. Her cells activate gamma-activated factor (GAF) STAT1 homodimers but not IFN-stimulated gene factor 3 (ISGF3) trimers (STAT1/STAT2/IRF9) in response to IFN-α2b. The transcriptome induced by IFN-α2b in the patient's cells is much narrower than that of control cells; however, induction of a subset of IFN-stimulated gene transcripts remains detectable. In vitro, the patient's cells do not control three respiratory viruses, influenza A virus (IAV), parainfluenza virus (PIV), and respiratory syncytial virus (RSV). These phenotypes are rescued by wild-type IRF9, whereas silencing IRF9 expression in control cells increases viral replication. However, the child has controlled various common viruses in vivo, including respiratory viruses other than IAV. Our findings show that human IRF9- and ISGF3-dependent type I and III IFN responsive pathways are essential for controlling IAV

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Wpływ przedsiębiorczości i czynników środowiskowych na przedsiębiorczą intencję sektora bankowego Indonezji

The current study aims to investigate the impact of four exogenous variables, namely, entrepreneurial orientation, entrepreneurial education, environmental factors, college experience toward the entrepreneurial intention of banking sector of Indonesia. To achieve this objective, data has been collected from the 450 managers of the banking sectors, and PLS-SEM was used to test the hypotheses. The key findings of the study have shown that entrepreneurial orientation, college experience, and environmental factors have a positive and significant effect on the entrepreneurial intention of banking sector of Indonesia. Based on the findings of the study, there are several practical and theoretical implications. The findings of the study could provide help to the policymakers to know about the importance to increase the entrepreneurial intention by the following exogenous variables. The findings of the study could also provide help to the researchers to conduct future research to increase the importance of the following study.Obecne badanie ma na celu zbadanie wpływu czterech zmiennych egzogenicznych, a mianowicie: orientacji przedsiębiorczej, edukacji przedsiębiorczej, czynników środowiskowych, doświadczenia uczelni na intencję przedsiębiorczości sektora bankowego w Indonezji. Aby osiągnąć ten cel, zebrano dane od 450 menedżerów sektorów bankowych, a do przetestowania hipotez wykorzystano PLS-SEM. Kluczowe wyniki badania wykazały, że orientacja na przedsiębiorczość, doświadczenie w nauce i czynniki środowiskowe mają pozytywny i znaczący wpływ na intencję przedsiębiorczości sektora bankowego w Indonezji. W oparciu o wyniki badania istnieje kilka praktycznych i teoretycznych implikacji. Wyniki badania mogą pomóc decydentom w zrozumieniu znaczenia zwiększenia intencji przedsiębiorczości przez następujące zmienne egzogeniczne. Wyniki badania mogą również pomóc naukowcom w przeprowadzeniu przyszłych badań w celu zwiększenia znaczenia następnego badania